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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3056

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
2585 2017년 한국 이공계 대학원생 캐나다 연수프로그램 추가 공모 박재홍 2017-04-12 3890 첨부파일 다운로드
2584 [IIT-BMSE Seminar] April 14(Fri.)14:30~/ Yong Jin Kim, MD Ph.D.(Guro Hospital, Korea Univ.)/ Dasan bldg. #109 박민서 2017-04-12 3152
열람중 [IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109 박민서 2017-04-12 3057
2582 [EECS Colloquium] 4/13(Thu.) 16:00~, Nitrogen-Vacancy Color Center in Diamond and its Applications, Dr. Jeong Hyun SHIM (KRISS) 정아영 2017-04-11 3757
2581 [매경-GIST FORUM] 행사 동영상 및 자료집 게시 대외협력팀 2017-04-11 3663 첨부파일 다운로드
2580 [SESE Seminar] 04.13.(Thu.) 16:00~ /Dr. Tae-Jin Park 김근영 2017-04-11 3861
2579 [화학과 Seminar] 04.11. (Tue.) 16:00 / Prof. Ki-Bum Lee (Rutgers University) 김은화 2017-04-11 3595
2578 [신소재공학부 Colloquium] 4.13.(Thur). 16:00~/ Prof. Jo, Moon-Ho (POSTECH) 최미나 2017-04-10 3811
2577 2017년도 미래 신산업창출 기획과제 공모 안내 박지혜 2017-04-10 3168 첨부파일 다운로드
2576 [화학과 Seminar] 04.13. (Thu.) 16:00 / Prof. Minyoung Yoon (Gachon University) 김은화 2017-04-10 3291 첨부파일 다운로드
2575 2017학년도 1학기 과학기술과 경제 제3강 안내(4/11(화) 송종국 과학기술정책연구원장) 김미림 2017-04-07 3815
2574 [재공지] 2017 테크니온 대학 창업교육 프로그램 대학원생 선발안내 유지돈 2017-04-07 3765 첨부파일 다운로드
2573 [IIT Seminar-SIT] 4/6(Thurs.)17:30~/ Prof.Bruce Alexander MacDonald/ Dasan bldg. #109 이지혜 2017-04-06 3577 첨부파일 다운로드
2572 [IIT Seminar-SIT] 4/7(Fri.14:30~), Prof.Sung-eui Yoon(KAIST), RISE bldg.#105 이지혜 2017-04-06 3062 첨부파일 다운로드
2571 [IIT Seminar] 4/7(Fri.)14:30~/ 양종아(전 MBC아나운서)/ Dasan bldg. #109 박민서 2017-04-06 3841
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