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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3423

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
2893 2017 산림 ICT 컨퍼런스 개최 안내 전체관리자 2017-10-19 3929 첨부파일 다운로드
2892 The 1st International symposium on Cell Logistics 개최 안내 이강은 2017-10-18 3363
2891 [생명과학부 Seminar-26] 2017.10.19.(Thu) 4:00pm, Gap Ryol Lee, PhD 이정민 2017-10-18 3916 첨부파일 다운로드
2890 2017.10.23.(월) 제2학2층식당(락락) 이용 중단 안내 주용구 2017-10-18 3993
2889 [물리광과학과 Colloquium] 10.18.(WED). 16:30~/ Prof. Hyungkook Choi(Chonbuk National University) 박다빈 2017-10-17 4614 첨부파일 다운로드
2888 [국립아시아문화전당] Open LAB 프로그램 크리에이터스 공모 전체관리자 2017-10-17 3626 첨부파일 다운로드
2887 [과제 공모] 차세대에너지연구소 시연과제 수행 연구팀 추가 공모 김은영 2017-10-17 3134 첨부파일 다운로드
2886 [언어교육센터]영어워크숍(제6차) "Body Language for Presentation" 임현진 2017-10-17 2951
2885 "GIST 후원의 집을 찾아라" 이벤트 결과안내 이슬 2017-10-16 3372
2884 [지구·환경공학부 Seminar] 2017.10.19.(Thu.) 4PM/Ph.D. Ellis Penning 박민서 2017-10-16 3304
2883 [창업진흥센터] 2017 GIST CEO FORUM 안내 안서영 2017-10-16 4633
2882 [GIST대학] 10/19(목) GIST대학 콜로퀴움 / 김영준 UST 교수 / 3차원 의료용 소프트웨어 기술 및 응용사례 김미애 2017-10-13 3751
2881 럭키소촌 차세대 작가 레지던스 '작가의 사생활' 전시 안내 전체관리자 2017-10-13 3495
2880 [ME Seminar] 3:00 PM, Oct. 17(Tue.), Dr. 이종서(Univ. of Liege, Belgium) 김수연 2017-10-12 4070 첨부파일 다운로드
2879 [생명과학부 Seminar-25] 2017.10.12.(Thu) 4:00pm, Sihyun Ham, PhD 이정민 2017-10-12 3893 첨부파일 다운로드
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