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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3385

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
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2865 [과제 공모] 차세대에너지연구소 시연과제 수행 연구팀 공모 김은영 2017-09-28 3124 첨부파일 다운로드
2864 [공고] 광주과학기술원 입주 스타트업 투자기업 모집공고 백난아 2017-09-28 3505 첨부파일 다운로드
2863 [IIT][SIT Seminar] 9/28(Thurs.14:30~)/ Director. Kim Hyung Jin (Green Energy Research Institute)/ Dasan bldg. #109 이지혜 2017-09-27 3021 첨부파일 다운로드
2862 [지구환경공학부 Seminar] 2017.09.28.(Thu.) 4PM/Ph.D. Bae, Mins-Suk 박민서 2017-09-27 2554
2861 [언어교육센터] 2017 영어 스피치 콘테스트 안내 임현진 2017-09-26 3695
2860 [LEC] 제9차 이공계 영어논문 작성법 특강 시리즈(총 4회) 임현진 2017-09-26 2804
2859 [상담경력개발센터] 2017 재학생 성격검사 실시 안내 박행자 2017-09-26 2912
2858 [IIT] BMSE Seminar, september 29 (14:30~) , Ph.D. Seung-Min Lee. Dasan bldg.#109 천애란 2017-09-26 2466
2857 [ME Seminar] 4:00 PM, Oct. 11(Wed.), Prof. 이승철(UNIST) 김수연 2017-09-25 2696 첨부파일 다운로드
2856 [GIST대학] 9/28(목) GIST대학 콜로퀴움 / 김진우 KAIST 교수 / 동물의 눈과 시각 발달 김미애 2017-09-25 2771
2855 [ME Seminar] 4:00 PM, Oct. 12(Thur.), Prof. 이경원(한국산업기술대) 김수연 2017-09-25 2946 첨부파일 다운로드
2854 2017학년도 2학기 과학기술과 경제 제3강 안내(9/26(화) 신정호 대표) 김미림 2017-09-25 3734
2853 [언어교육센터] LEC 스피치 콘테스트 개최합니다. 임현진 2017-09-22 3803
2852 [GIST Library] 2nd GIST Movie Night 이지현 2017-09-22 3459
2851 2017년도 제3차 과학기술출연기관장협의회 정기회의 개최 안내 최용혁 2017-09-22 2975
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