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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3450

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
2909 세미나 취소 - [생명과학부 Seminar-29] 2017.11.02.(Thu) 4:00pm, Wahn Soo Choi, PhD 이정민 2017-10-30 3300 첨부파일 다운로드
2908 [11/03(Fri.) 15:00] ME Seminar 김수연 2017-10-30 3248 첨부파일 다운로드
2907 [GIST 상담경력개발센터] 재학생 성격검사 결과 해석상담 안내 박행자 2017-10-27 3433
2906 [대외협력팀] GIST 동문 컨퍼런스 & 동문의 밤(재학생 참여가능) 이슬 2017-10-27 4340 첨부파일 다운로드
2905 [GIST Conference(ME Seminar)] 11/03(Fri.) 14:00~17:40 김수연 2017-10-26 3591
2904 [국립광주과학관] 제10회 필 사이언스 강연 '생명의 빛, 오로라' 전체관리자 2017-10-26 3772
2903 실험동물자원센터(LARC) 심포지엄 개최 안내 (11.01) 전체관리자 2017-10-26 3480
2902 [IIT-SIT Seminar] 10/26(Thurs.14:30~)/ Prof. Kwak Sung-Jo(GIST) Dasan bldg. #109 이지혜 2017-10-25 3965 첨부파일 다운로드
2901 [언어교육센터] 영어워크숍(7차) "Fake news" 임현진 2017-10-25 3450
2900 [IIT] BMSE Seminar, October 26 (16:00~) , Ph.D. HyungJoon Cho. Dasan bldg.#109 천애란 2017-10-23 3381
2899 [화학과 Seminar] 10.26. (Tue.) 16:00 / Prof. Hyunseob Lim (Chonnam National University) 김은화 2017-10-23 3196 첨부파일 다운로드
2898 [언어교육센터] '영어교과목' 설문조사 실시 임현진 2017-10-23 3304
2897 [ME Seminar] 2:30 PM, Oct. 25(Wed.), 저속 풍동 설계의 기초 정지현 2017-10-20 3485
2896 [생명과학부 Seminar-28] 2017.10.30.(Mon) 4:00pm, Jiyeon Kim, PhD 이정민 2017-10-20 3439
2895 [생명과학부 Seminar-27] 2017.10.26.(Thu) 4:00pm, Soo-Youl Kim, PhD 이정민 2017-10-20 2901
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