본문 바로가기 사이드메뉴 바로가기 주메뉴 바로가기

GISTian

Students are the heart and soul of GIST

GIST NEWS
GIST, 우체국금융개발원(PoSID), 금융·AI 융합인재 양성 및 지역 상생 위한 협약 체결 사진
2025.11.25 10:05:46

GIST, 우체국금융개발원(PoSID), 금융·AI 융합인재 양성 및 지역 상생 위한 협약 체결
GIST, 기술경영전문대학원 산학연협의회 출범 … 미래모빌리티 학술대회도 연계 개최 사진
2025.11.24 09:35:04

GIST, 기술경영전문대학원 산학연협의회 출범 … 미래모빌리티 학술대회도 연계 개최
GIST NEWS 더보기
Vision
Research
Campus Tour

공지사항

[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3351

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

목록
총 5436건 / 오늘 0건
공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
2841 [언어교육센터] 2017 가을학기 워크숍 일정 안내 임현진 2017-09-19 2576
2840 [차세대에너지연구소] Risk Management in Electricity Markets / Dr. Manho Joung(미 Sempra Energy) 김은영 2017-09-18 2931
2839 제9회 광주 한독공동학술대회 ADeKo 안내 전체관리자 2017-09-18 3989 첨부파일 다운로드
2838 [상담경력개발센터] 기숙사 방문 앞 스티커 부착 안내 박행자 2017-09-18 2762
2837 임시공휴일(2017.10.02) 시행 안내 전체관리자 2017-09-18 3014
2836 [화학과 Seminar] 09.21. (Thu.) 16:00 / Dr. Sehoon Park (KAIST) 김은화 2017-09-18 2434 첨부파일 다운로드
2835 2017 루키 메이커톤 챌린지 전체관리자 2017-09-18 3367 첨부파일 다운로드
2834 2017년 2학기 신입생 성격검사 결과 해석상담 안내 박행자 2017-09-15 2685
2833 2017 전국 청년 창업 아이디어 경진대회 김상숙 2017-09-14 3508
2832 [신소재공학부 Colloquium] 09.14.(Thur.) 16:00~/Dr. Kwon, Ick Chan(KIST) 기민정 2017-09-13 2784
2831 [IIT][SIT Seminar] 9/14(Thurs.14:30~)/ DR. Cho Sook-Kyoung (국립광주과학관)/ Dasan bldg. #109 이지혜 2017-09-13 3000 첨부파일 다운로드
2830 [IIT] BMSE Seminar, september 21 (16:00~) , Ph.D. Jee Hyun Choi. Dasan bldg.#109 천애란 2017-09-13 2598
2829 [언어교육센터] 영어워크숍(1차): "Discovering New English Dramas" 정명하 2017-09-12 2622
2828 2017학년도 2학기 과학기술과 경제 제2강 안내(9/12(화) 김윤이 대표) 김미림 2017-09-11 3334
2827 [GIST대학] 9/14(목) GIST대학 콜로퀴움 / 김진경 영산대 교수 / 역사와 미래-올바른 역사인식이 미래를 창출한다. 김미애 2017-09-11 2857
첫페이지이전페이지171172173174175176177178179180다음페이지마지막페이지
첫페이지이전페이지
174 / 363
다음페이지마지막페이지