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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3526

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
2976 2017 GIST 과학스쿨 플러스 특별강연 안내(11.24.18:30, 오룡관) 이혜진 2017-11-22 3940
2975 2017 사회공헌단 배움마당 교류행사 안내(11.24.17:00, 오룡관) 최진숙 2017-11-22 3943
2974 [GIST대학] 11/23(목)GIST대학 콜로퀴움 / 이강택 교수 / 나노 내비게이션 (Nano GPS) 김미애 2017-11-22 4331
2973 [11/24(Fri.) 13:30] ME Seminar 김수연 2017-11-21 4345 첨부파일 다운로드
2972 [IIT][SIT Seminar] 11/23(Thurs.14:30~)/ Prof. Sunghyun Cho(DGIST)/ Dasan bldg. #109 이지혜 2017-11-21 4936 첨부파일 다운로드
2971 [물리광과학과 Colloquium] 11.24.(FRI). 16:30~/Prof. Jeehoon Kim(POSTECH) 박다빈 2017-11-21 4140 첨부파일 다운로드
2970 [물리광과학과 Colloquium] 11.22.(WED). 16:30~/Prof. Gun-Sik Park(Seoul National University) 박다빈 2017-11-21 4211 첨부파일 다운로드
2969 [GIST Library] GIST대학 천문동아리 SPACEBAR 전시회 안내 이지현 2017-11-21 3820
2968 2017년 겨울학기 산학협력인턴십(CUop program) 참여 학생 모집 안내 김동준 2017-11-21 4860 첨부파일 다운로드
2967 [GIST Library] The 2nd Collaboration 악동XGISRI 이지현 2017-11-21 3984
2966 [신소재공학부 Seminar] 2017.11.24.(Fri.) 16:00 / Prof. Kim, Dong Kyu 정세온 2017-11-21 3621
2965 [11/28(Tue.) 13:00] ME Seminar 김수연 2017-11-20 3739
2964 [11/22(Wed.) 16:00] ME Seminar 김수연 2017-11-20 3730
2963 [신소재공학부 Colloquium] 11.23.(Thur.) 16:00~/Prof. Son,Young-Woo(School of Computational Sciences.Korea Institute for Advanced Study) 정세온 2017-11-20 3262
2962 [지구환경공학부 Seminar] 2017.11.23.(Thu.) 4PM/Prof. Yoon-E Choi 박민서 2017-11-20 3734
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