The human body is soft, curvilinear, and time-dynamic; modern devices are rigid, boxy, and physically static. Due to the profound mismatch in properties, conventional manufacturing technologies cannot provide routes to produce desired biomedical devices which can be laminated on the skin or implanted into the body. For this reason, new manufacturing strategies need to be developed by shifting many aspects in processing mechanisms, structural design, mechanics, and machine tools. In this seminar I will discuss new approaches to develop soft biomedical devices including textile mounted electronics, skin-like substrate, and 3D coil structure. These novel processes and device designs are great potentials to conduct highly reliable and cost-effective biomedical system. These are fully compatible with well-established manufacturing technologies which encompass from traditional manufacturing to N/MEMS. Thus, this practical approach will provide promising engineering tools for newly emerging biomedical applications.