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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3500

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
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2963 [신소재공학부 Colloquium] 11.23.(Thur.) 16:00~/Prof. Son,Young-Woo(School of Computational Sciences.Korea Institute for Advanced Study) 정세온 2017-11-20 3249
2962 [지구환경공학부 Seminar] 2017.11.23.(Thu.) 4PM/Prof. Yoon-E Choi 박민서 2017-11-20 3720
2961 [생명과학부 Seminar-34] 2017.11.23.(Thu) 4:00pm, Young-Joon Kim, PhD 이정민 2017-11-20 3332
2960 [생명과학부 Seminar-33] 2017.11.22.(Wed) 4:00pm, Sang-Jun Ha, PhD 이정민 2017-11-20 3317
2959 2018년 지스트꿈빛어린이집 원아 모집 안내 주용구 2017-11-20 5602 첨부파일 다운로드
2958 [화학과 Seminar] 11.23. (Thu.) 16:00 / Dr. Jongho Jeon (KAERI) 김은화 2017-11-20 3481 첨부파일 다운로드
2957 [GIST Library] 박찬갑 조각가 초청강연 안내 이지현 2017-11-16 3855 첨부파일 다운로드
2956 GIST 연구성과 토크콘서트 안서영 2017-11-16 4587 첨부파일 다운로드
2955 미래사회 혁신선도 GIST 연구성과 전시회 전체관리자 2017-11-16 5961 첨부파일 다운로드
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2953 [IIT] BMSE Seminar, November 17 (14:30~) , Ph.D. Seok Chung. Dasan bldg.#109 천애란 2017-11-15 3164
2952 [세포로지스틱스연구센터 Seminar] 11.28. (Tue.) 16:00 / Prof. Hyun-Woo Rhee (UNIST) 이강은 2017-11-15 3906 첨부파일 다운로드
2951 [언어교육센터] 영어 스피치 콘테스트에 초대합니다 임현진 2017-11-14 3951
2950 [물리광과학과 Colloquium] 11.15.(WED). 16:30~/Prof. Hosung Seo(Ajou University) 박다빈 2017-11-14 5204 첨부파일 다운로드
2949 [물리광과학과 Colloquium] 11.14.(TUE). 16:00~/Dr. Cheolho Jeon(KBSI) 박다빈 2017-11-14 3657 첨부파일 다운로드
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