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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3559

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
3011 2017년 겨울학기 수강신청 안내 박재홍 2017-12-12 4045 첨부파일 다운로드
3010 [물리광과학과 Colloquium] 12.8.(WED). 16:30~/Prof. WANIL PARK(Chonbuk National University) 박다빈 2017-12-08 4005 첨부파일 다운로드
3009 [물리광과학과 Colloquium] 12.8.(WED). 15:00~/Dr.Yong Su Kim, Dong Jin Yun(Samsung Advanced Institute of Technology) 박다빈 2017-12-08 4172 첨부파일 다운로드
3008 [IIT][SIT Seminar] 12/7(Thurs.14:30~)/ Prof. Chun T. Rim(GIST)/ Dasan bldg. #109 이지혜 2017-12-06 4032 첨부파일 다운로드
3007 [12/07(Thur.) 16:30] ME Seminar 김수연 2017-12-05 4249 첨부파일 다운로드
3006 [GIST Library] 이혜선 x 김유진 작가 초대전(바늘끝 감성) 이지현 2017-12-05 3985 첨부파일 다운로드
3005 [지구환경공학부 Seminar] 2017.12.07.(Thu.) 4PM/Prof. Sae Yun Kwon 박민서 2017-12-05 3502
3004 [생명과학부 Seminar-38] 2017.12.14.(Thu) 4:00pm, Sunglim Cho, PhD 이정민 2017-12-04 4012
3003 [생명과학부 Seminar-37] 2017.12.13.(Wed) 2:00pm, Young-sup Yoon, PhD 이정민 2017-12-04 3672
3002 [화학과 Seminar] 12.07. (Thu.) 16:00 / Prof. Hyun-Dam Jeong (Chonnam National University) 김은화 2017-12-04 3998 첨부파일 다운로드
3001 싱가포르 투자전문 기관 Golden Equator 초청 투자전략 세미나 개최 안내 최용혁 2017-12-02 4073
3000 [특별세미나] GIST-IERI & UNU-INWEH 워크샵 및 2018 UNU 인턴쉽 프로그램 소개 조은경 2017-12-01 4647
2999 [신소재공학부 Seminar] 2017.12.14.(Thur.) 16:00 / Prof. Jung, Hee Tae 정세온 2017-11-30 3639
2998 [신소재공학부 Seminar] 2017.12.04.(Mon.) 16:00 / Prof. Kim, Youn Sang 정세온 2017-11-30 3469
2997 [신소재공학부 Seminar] 2017.12.04.(Mon.) 15:00 / Prof. Kim, Sang-Woo 정세온 2017-11-30 3670
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