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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

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  • 등록일 : 2017.04.12
  • 조회수 : 3493

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
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2959 2018년 지스트꿈빛어린이집 원아 모집 안내 주용구 2017-11-20 5591 첨부파일 다운로드
2958 [화학과 Seminar] 11.23. (Thu.) 16:00 / Dr. Jongho Jeon (KAERI) 김은화 2017-11-20 3474 첨부파일 다운로드
2957 [GIST Library] 박찬갑 조각가 초청강연 안내 이지현 2017-11-16 3850 첨부파일 다운로드
2956 GIST 연구성과 토크콘서트 안서영 2017-11-16 4582 첨부파일 다운로드
2955 미래사회 혁신선도 GIST 연구성과 전시회 전체관리자 2017-11-16 5956 첨부파일 다운로드
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2953 [IIT] BMSE Seminar, November 17 (14:30~) , Ph.D. Seok Chung. Dasan bldg.#109 천애란 2017-11-15 3157
2952 [세포로지스틱스연구센터 Seminar] 11.28. (Tue.) 16:00 / Prof. Hyun-Woo Rhee (UNIST) 이강은 2017-11-15 3901 첨부파일 다운로드
2951 [언어교육센터] 영어 스피치 콘테스트에 초대합니다 임현진 2017-11-14 3947
2950 [물리광과학과 Colloquium] 11.15.(WED). 16:30~/Prof. Hosung Seo(Ajou University) 박다빈 2017-11-14 5199 첨부파일 다운로드
2949 [물리광과학과 Colloquium] 11.14.(TUE). 16:00~/Dr. Cheolho Jeon(KBSI) 박다빈 2017-11-14 3654 첨부파일 다운로드
2948 과학기술정보통신부 <열린정책자문단> 모집 전체관리자 2017-11-13 3626 첨부파일 다운로드
2947 [화학과 Seminar] 11.16. (Thu.) 16:00 / Prof. Min Hee Lee (Sookmyung Women's University) 김은화 2017-11-13 3795 첨부파일 다운로드
2946 [언어교육센터]영어 워크숍(9차) "What a pain: Expressing illness and injury" 임현진 2017-11-13 3431
2945 [언어교육센터]영어 워크숍(8차) "Basic Writing" 임현진 2017-11-13 3796
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