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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

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  • 등록일 : 2017.04.12
  • 조회수 : 3357

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
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2856 [GIST대학] 9/28(목) GIST대학 콜로퀴움 / 김진우 KAIST 교수 / 동물의 눈과 시각 발달 김미애 2017-09-25 2757
2855 [ME Seminar] 4:00 PM, Oct. 12(Thur.), Prof. 이경원(한국산업기술대) 김수연 2017-09-25 2930 첨부파일 다운로드
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2853 [언어교육센터] LEC 스피치 콘테스트 개최합니다. 임현진 2017-09-22 3788
2852 [GIST Library] 2nd GIST Movie Night 이지현 2017-09-22 3438
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2850 [화학과 Seminar] 09.26. (Tue.) 16:00 / Prof. Woon Ju Song (Seoul National University) 김은화 2017-09-22 2959 첨부파일 다운로드
2849 [에너지밸리기술원] 제15회 에너지 전문가 포럼 개최 안내 임주희 2017-09-21 3192 첨부파일 다운로드
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2847 [신소재공학부 On the Industrial Applications of Advanced Materials] 09.26.(Tue.) 16:00~18:00/Dr. Kim, Do-Geun (Korea Institute of Materials Science) 최미나 2017-09-21 2886
2846 [신소재공학부 Colloquium] 09.28.(Thur.) 16:00~/Prof. Choo, Jaebum (Department of Bionano Engineering, Hanyang Univ.) 최미나 2017-09-21 2832
2845 [ME Seminar] 4:00 PM, Sep. 28(Thur.), Prof. 김대경(순천대) 김수연 2017-09-20 3066 첨부파일 다운로드
2844 2017 한글날 기념 "외래어 및 로마자 표기법" 워크숍 안내(10.13) 정명하 2017-09-20 2976
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