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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3476

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
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2949 [물리광과학과 Colloquium] 11.14.(TUE). 16:00~/Dr. Cheolho Jeon(KBSI) 박다빈 2017-11-14 3646 첨부파일 다운로드
2948 과학기술정보통신부 <열린정책자문단> 모집 전체관리자 2017-11-13 3616 첨부파일 다운로드
2947 [화학과 Seminar] 11.16. (Thu.) 16:00 / Prof. Min Hee Lee (Sookmyung Women's University) 김은화 2017-11-13 3785 첨부파일 다운로드
2946 [언어교육센터]영어 워크숍(9차) "What a pain: Expressing illness and injury" 임현진 2017-11-13 3425
2945 [언어교육센터]영어 워크숍(8차) "Basic Writing" 임현진 2017-11-13 3789
2944 [교육안내] GIST 고령친화산업지원센터 유니버설디자인 적용방안 교육 안내 지유강 2017-11-10 3440 첨부파일 다운로드
2943 [신소재공학부 Colloquium] 11.16.(Thur.) 16:00~/Prof. Park, Tai Hyun(School of Chemical and Biological Engineering, Seoul University) 정세온 2017-11-10 3237 첨부파일 다운로드
2942 [신소재공학부 On the Industrial Applications of Advanced Materials] 11.14.(Tue.) 16:00~18:00/안준환 수석연구원(롯데화학) 정세온 2017-11-10 3548 첨부파일 다운로드
2941 [11/29(Wed.) 14:30 & 16:00] ME Seminar 김수연 2017-11-09 3248
2940 2017 GIST 문화의 밤 Culture Night 안내 전체관리자 2017-11-09 5256
2939 [GIST-NIA 공동파견] 2017년 월드프렌즈 ICT봉사단 귀국발표회 안내 (11/10(금) 17:30) 김지훈 2017-11-09 3509
2938 2017년 학생축제 - Lumière 개최 안내 김지훈 2017-11-08 4569
2937 [IIT][SIT Seminar] 11/10(Fri.16:00~)/ Seung-Jong Kim, Ph.D(KIST)/ Dasan bldg. #109 이지혜 2017-11-07 3301
2936 [IIT][SIT Seminar] 11/9(Thurs.14:30~)/ Prof. Jinho Kim(GIST) Dasan bldg. #109 이지혜 2017-11-07 3718
2935 [생명과학부 Seminar-32] 2017.11.16.(Thu) 4:00pm, Seungbok Lee, PhD 이정민 2017-11-07 3508
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