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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

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  • 등록일 : 2017.04.12
  • 조회수 : 3461

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
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2938 2017년 학생축제 - Lumière 개최 안내 김지훈 2017-11-08 4554
2937 [IIT][SIT Seminar] 11/10(Fri.16:00~)/ Seung-Jong Kim, Ph.D(KIST)/ Dasan bldg. #109 이지혜 2017-11-07 3294
2936 [IIT][SIT Seminar] 11/9(Thurs.14:30~)/ Prof. Jinho Kim(GIST) Dasan bldg. #109 이지혜 2017-11-07 3712
2935 [생명과학부 Seminar-32] 2017.11.16.(Thu) 4:00pm, Seungbok Lee, PhD 이정민 2017-11-07 3502
2934 [UST] 2017년 동계 연구인턴십 참여 안내 박재홍 2017-11-07 4113
2933 [물리광과학과 Colloquium] 11.9.(THU). 16:30~/Prof. Stevan Nadj-Perge 박다빈 2017-11-06 3534 첨부파일 다운로드
2932 [물리광과학과 Colloquium] 11.8.(WED). 15:00~18:00, Dr. Toru Shimada/Prof. Jaewook Ahn 박다빈 2017-11-06 3453 첨부파일 다운로드
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2929 [생명과학부 Seminar-31] 2017.11.09.(Thu) 4:00pm, Dong Ho Woo, PhD 이정민 2017-11-06 3831
2928 [생명과학부 Seminar-30] 2017.11.09.(Thu) 3:00pm, Seok-Kyu Kwon, PhD 이정민 2017-11-06 3237
2927 [GIST Library] 김락겸 작가 초대전(도예전시) 이지현 2017-11-06 3433
2926 [GIST 상담경력개발센터] 또래상담자 정신건강 캠페인 안내 박행자 2017-11-06 3244
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2924 [화학과 Seminar] 11.09. (Thu.) 16:00 / Prof. So-Jung Park (Ewha Womans University) 김은화 2017-11-06 3743 첨부파일 다운로드
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