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[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3545

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

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3002 [화학과 Seminar] 12.07. (Thu.) 16:00 / Prof. Hyun-Dam Jeong (Chonnam National University) 김은화 2017-12-04 3986 첨부파일 다운로드
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3000 [특별세미나] GIST-IERI & UNU-INWEH 워크샵 및 2018 UNU 인턴쉽 프로그램 소개 조은경 2017-12-01 4631
2999 [신소재공학부 Seminar] 2017.12.14.(Thur.) 16:00 / Prof. Jung, Hee Tae 정세온 2017-11-30 3628
2998 [신소재공학부 Seminar] 2017.12.04.(Mon.) 16:00 / Prof. Kim, Youn Sang 정세온 2017-11-30 3462
2997 [신소재공학부 Seminar] 2017.12.04.(Mon.) 15:00 / Prof. Kim, Sang-Woo 정세온 2017-11-30 3662
2996 [KISTI] 제7회 EDISON SW 활용 경진대회 참가 안내 박재홍 2017-11-30 4045 첨부파일 다운로드
2995 2018년도 실용화과제 공모 전현진 2017-11-30 4801 첨부파일 다운로드
2994 제 1회 국제안보과학기술 워크숍 개최 안내(2017.12.06. 목. 14:00 ~ ) 신유진 2017-11-29 4262 첨부파일 다운로드
2993 [지구환경공학부 Seminar] 2017.11.30.(Thu.) 4PM/Prof. Jeongdong Choi 박민서 2017-11-29 3739
2992 [물리광과학과 Colloquium] 11.29.(WED). 16:30~/Dr. Hee Chul Park(IBS) 박다빈 2017-11-28 3651 첨부파일 다운로드
2991 [언어교육센터] 영어 워크숍(10차) "Improving your academic scholarship as a GIST student" 임현진 2017-11-28 3303
2990 [GIST대학] 11/30(목)GIST대학 콜로퀴움 / 신성철 KAIST 총장 / 행복한 미래를 위한 GISTians의 준비 김미애 2017-11-28 3250
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2988 [화학과 Seminar] 11.30. (Thu.) 16:00 / Dr. Jung-Woo Park (IBS-KAIST) 김은화 2017-11-27 3188 첨부파일 다운로드
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