본문 바로가기 사이드메뉴 바로가기 주메뉴 바로가기

GISTian

Students are the heart and soul of GIST

GIST NEWS
GIST, '고정주 커뮤니티라운지' 신축… 총장 관사가 모두의 열린 공간으로 사진
2025.11.14 10:25:15

GIST, '고정주 커뮤니티라운지' 신축… 총장 관사가 모두의 열린 공간으로
GIST-MIT 공동연구 심포지엄 개최… 5년 공동연구 AI 융합연구 성과 총집합 사진
2025.11.13 10:24:16

GIST-MIT 공동연구 심포지엄 개최… 5년 공동연구 AI 융합연구 성과 총집합
GIST NEWS 더보기
Vision
Research
Campus Tour

공지사항

[IIT-BMSE Seminar] April 13(Thu.)16:00~/ Jaemyoung Suh, Ph.D.(KAIST)/ Dasan bldg. #109

  • 박민서
  • 등록일 : 2017.04.12
  • 조회수 : 3346

BMSE SEMINAR Thursday, April 13, 2017, 4:00 PM Dasan Bldg. 109 (1s‘ F loor) (Host: Prof Steve K. Chn / Language: Englixh) From Feast to Famine: Biology and Pharmacology of Fibroblast Growth Factor 1 (FGF1) Jaemyoung Suh, Ph.D. Assistant Professor Graduate School 0fMedical Science and Engineering, KAIST The ability to adapt to cycles offeast and famine is critical for survival. As part of a screen to identify genes that respond to feast and famine cues, we discovered that in white adipose tissue (WAT) PPAR}! induces FGFI in response to high-fat-diet (I-IFD) and it is repressed during a fast. Because FGFl- deiticient mice are normal, it was thought to be a nonessential gene. Hoxvever, on HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose progressively becoming dysmorphic, fibrotic and necrotic and unable to adapt to nutrient stress. Thus, though seemingly dispensable under standard laboratory rearing conditions, within the context of feast and famine FGFI is critical for survival. We next explored the therapeutic potential of synthetic FGF1 in treating diabetic disease models. Surprisingly, we found FGF1 by simple injection restores insulin sensitivity in obese diabetic mice. This effect is rapid, robust, and without desensitization upon long—term administration. Studies 011 FGP1 derivatives reveal the structure—f'unctio11 space to be malleable and robust. Notably, we identified an N-terminal truncation of FGF1 in which ntitogenicity can be eliminated while retaining full glucose lowering action. Thus, ‘endocrinized’ FGFl is a potent metabolic regulator and shows promise as a new therapeutic modality in the management of Type II diabetes. Biography Dr. Suh is currently an assistant professor in the Graduate School of Medical Science and Engineering at KAIST. He has worked on the development and function of adipose tissues in both vertebrate and invertebrate model systems. Recently, he has been focusing on nuclear receptor~growth factor axes in tissue homeostasis and metabolic flexibility. His overarching goal is to understand the complex response to nutrient fluctuation and identify new therapeutic opportunities to treat metabolic disease. Integrated Institute of Technology(IIT)/Deparment of Biomedical Science and Engineering(BMSE)

목록
총 5430건 / 오늘 0건
공지사항 - 번호, 제목, 작성자, 작성일, 조회수, 첨부파일 정보제공
번호 제목 작성자 작성일 조회수 첨부파일
2850 [화학과 Seminar] 09.26. (Tue.) 16:00 / Prof. Woon Ju Song (Seoul National University) 김은화 2017-09-22 2955 첨부파일 다운로드
2849 [에너지밸리기술원] 제15회 에너지 전문가 포럼 개최 안내 임주희 2017-09-21 3185 첨부파일 다운로드
2848 GIST 스물다섯 가지 이야기 공모 안내 박세미 2017-09-21 3886
2847 [신소재공학부 On the Industrial Applications of Advanced Materials] 09.26.(Tue.) 16:00~18:00/Dr. Kim, Do-Geun (Korea Institute of Materials Science) 최미나 2017-09-21 2880
2846 [신소재공학부 Colloquium] 09.28.(Thur.) 16:00~/Prof. Choo, Jaebum (Department of Bionano Engineering, Hanyang Univ.) 최미나 2017-09-21 2824
2845 [ME Seminar] 4:00 PM, Sep. 28(Thur.), Prof. 김대경(순천대) 김수연 2017-09-20 3062 첨부파일 다운로드
2844 2017 한글날 기념 "외래어 및 로마자 표기법" 워크숍 안내(10.13) 정명하 2017-09-20 2970
2843 추석(명절) 연휴기간 식당이용 안내 주용구 2017-09-19 3425
2842 [대외협력팀] GIST 25주년 기념와인(주문서 업데이트) 이혜진 2017-09-19 7733 첨부파일 다운로드
2841 [언어교육센터] 2017 가을학기 워크숍 일정 안내 임현진 2017-09-19 2572
2840 [차세대에너지연구소] Risk Management in Electricity Markets / Dr. Manho Joung(미 Sempra Energy) 김은영 2017-09-18 2927
2839 제9회 광주 한독공동학술대회 ADeKo 안내 전체관리자 2017-09-18 3984 첨부파일 다운로드
2838 [상담경력개발센터] 기숙사 방문 앞 스티커 부착 안내 박행자 2017-09-18 2759
2837 임시공휴일(2017.10.02) 시행 안내 전체관리자 2017-09-18 3013
2836 [화학과 Seminar] 09.21. (Thu.) 16:00 / Dr. Sehoon Park (KAIST) 김은화 2017-09-18 2433 첨부파일 다운로드
첫페이지이전페이지171172173174175176177178179180다음페이지마지막페이지
첫페이지이전페이지
173 / 362
다음페이지마지막페이지