GIST College student Suin Jo publishes a review paper as the first-author in an SCI journal
□ Suin Jo, a senior life sciences major studying under Professor Chang-Duk Jun at GIST College (Dean Do-kyeong Ko) at the Gwangju Institute of Science and Technology (GIST, President Seung Hyeon Moon), has written a review paper * as the first-author that was entitled "Transgelin‐2 in immunity: Its implication in cell therapy" and published on May 11, 2018, in the Journal of Leukocyte Biology (impact factor of 4.289).
∘ Review articles are based on the latest developments in a field, and it is rare for undergraduate students to publish review papers in SCI journals.
□ Suin Jo is an undergraduate member of Professor Chang-Duk Jun's Immune Synapse and Cell Therapy Research Center, which for the past few years has been studying the biochemical characteristics of actin-binding protein * Transgelin-2 as well as its physiological mechanisms in the immune system to determine its feasibility in cancer immunotherapy.
∘ Cell-mediated immunotherapy is one of the areas of greatest interest in immunology with the ultimate goal of treating cancer.
∘ Transgelin-2 binds to actin and plays an important role in various actin-related signaling pathways such as actin filament structure stabilization and LFA-1-ICAM-1 axis. In particular, Transgelin-2 was found to be involved in immune system mechanisms including T cell activation, T cell-B cell interaction, and macrophage macrophage activation as the only transgelin present in white blood cells.
* Actin-binding protein: A generic term for various proteins involved in actin cytoskeleton polymerization or degradation (depolymerization) by binding to actin units or actin filaments
□ In this review paper, the authors analyzed the biochemical characteristics of Transgelin-2 and the physiological regulation and mechanism of actin in immune cells. Among them, cell-based cancer immunotherapy using Transgelin-2 T cell activation mechanism was discussed in detail.
□ This paper was supported by the Creative Research Initiative Program through National Research Foundation grants funded by the Ministry of Science ,ICT & Future Planning and Basic Science Program through National Research Foundation grants funded by the Ministry of Education,Korea.
